Active immunisation of pregnant heifers and cows in order to stimulate
the development of antibodies against bovine rotavirus, bovine
coronavirus and E. coli expressing F5 (K99) adhesin and to increase the
level of passive immunity of calves against neonatal diarrhoea caused by
bovine rotavirus, bovine coronavirus and E. coli expressing F5 (K99)
adhesin.

In calves fed with colostrum and milk from vaccinated cows for the first
week of life, laboratory studies conducted with heterologous challenge
strains (a G6 BRV strain, a BCV strain, and a K99 E. coli strain) have
demonstrated that these antibodies:
-Prevent neonatal diarrhoea caused by bovine rotavirus and E. coli
expressing F5 (K99) adhesin,
-Reduce the incidence and severity of neonatal diarrhoea caused by
bovine coronavirus,
-Reduce faecal shedding of virus in calves infected with bovine
rotavirus and bovine coronavirus.

Onset of immunity:
In calves fed with colostrum from vaccinated heifers or cows, passive
immunity commences with colostrum feeding and is dependent on calves
receiving sufficient colostrum after birth.

Duration of immunity:
Calves fed with colostrum and milk from vaccinated dams for the first
week of life are protected against bovine rotavirus for 7 days and
against bovine coronavirus for 14 days. The duration of immunity against
infections caused by E. coli expressing F5 (K99) adhesin was not studied
since such disease is usually observed in calves less than 3 days of age
and susceptibility to enterotoxigenic E. coli is age dependent.

£450.63