Benazecare is indicated for the treatment of congestive heart failure in dogs and the treatment of chronic renal insufficiency in cats. After oral administration, benazepril is rapidly absorbed from the gastrointestinal tract and hydrolysed into benazeprilat, a highly specific and potent inhibitor of angiotensin converting enzyme (ACE). In dogs with heart failure, benazeprilat lowers the blood pressure and volume loading effect on the heart.In cats with renal insufficiency, benazeprilat reduces the protein loss in urine and normalises the elevated glomerular capillary pressure and reduces systemic blood pressure. Reduction in glomerular hypertension retards the progression of kidney disease by inhibition of further damage to the kidneys. Benazepril has been shown to increase the appetite, quality of life and the survival time of cats particularly in advanced disease.
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